CUL5 CLIA Kit for Human(Homo sapiens) | EIAab.comCUL5 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CUL5(Gene name) > Human

CUL5 (Gene name),

Cullin-5 (Protein name ), CUL5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CUL5(VACM1);

Protein name:

Cullin-5(CUL-5);

Alternative:

Vasopressin-activated calcium-mobilizing receptor 1(VACM-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.

Function:

Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

780

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

780:

KMIKEQIEWL | IEHKYIRRDE | SDINTFIYMA |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q93034

Pfam:

PF00888

KEGG:

hsa:8065

SMR:

Q93034

MIM:

601741

STRING:

9606.ENSP00000299351

UniGene:

Hs.440320

Uniprot:

Q93034

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ELISA Kit for Human CUL-5

Cat.:

E15273h

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96T

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ELISA Kit for Human CUL-5

Cat.:

E15273m

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Packing:

96T

ELISA Kit for Human CUL-5

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ELISA Kit for Human CUL-5

Cat.:

E15273r

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96T

CLIA Kit for Human CUL-5

Cat.:

U15273h

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96T

CLIA Kit for Human CUL-5

Cat.:

U15273r

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Packing:

96T

CLIA Kit for Human CUL-5

Cat.:

U15273m

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Packing:

96T

CLIA Kit for Human CUL-5

MSDS:

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Polyclonal Antibody for Human CUL-5

Cat.:

P15273Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CUL-5

Cat.:

P15273Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human CUL-5

Cat.:

P15273Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human CUL-5

Protein for Human CUL-5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23."
Byrd P.J. , Stankovic T. , McConville C.M. , Smith A.D. , Cooper P.R. , Taylor A.M.R.
Genome Res.7:71-75(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Longo K.A. , North W.G. , Du J. , Fay M.J.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

Kanaya K. , Kamitani T.
Submitted (2000-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Testis.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
7.

"ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity."
Ohta T. , Michel J.J. , Schottelius A.J. , Xiong Y.
Mol. Cell3:535-541(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBX1 AND RNF7
8.

"Covalent modification of all members of human cullin family proteins by NEDD8."
Hori T. , Osaka F. , Chiba T. , Miyamoto C. , Okabayashi K. , Shimbara N. , Kato S. , Tanaka K.
Oncogene18:6829-6834(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NEDDYLATION
9.

"Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase."
Kamura T. , Burian D. , Yan Q. , Schmidt S.L. , Lane W.S. , Querido E. , Branton P.E. , Shilatifard A. , Conaway R.C. , Conaway J.W.
J. Biol. Chem.276:29748-29753(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN E3 UBIQUITIN-PROTEIN LIGASE COMPLEX WITH LRRC41;IDENTIFICATION IN A COMPLEX WITH TCEB3;IDENTIFICATION IN A COMPLEX WITH SOCS1;IDENTIFICATION IN A COMPLEX WITH WSB1
10.

"Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery."
Harada J.N. , Shevchenko A. , Shevchenko A. , Pallas D.C. , Berk A.J.
J. Virol.76:9194-9206(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH HUMAN ADENOVIRUS 5 PROTEINS;NEDDYLATION
11.

"Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation."
Mehle A. , Goncalves J. , Santa-Marta M. , McPike M. , Gabuzda D.
Genes Dev.18:2861-2866(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV VIF
12.

"VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases."
Kamura T. , Maenaka K. , Kotoshiba S. , Matsumoto M. , Kohda D. , Conaway R.C. , Conaway J.W. , Nakayama K.I.
Genes Dev.18:3055-3065(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE ECS(LRRC41) COMPLEX;IDENTIFICATION IN THE ECS(SOCS3) COMPLEX;IDENTIFICATION IN THE ECS(SPSB1) COMPLEX;IDENTIFICATION IN THE ECS(SPSB2) COMPLEX;IDENTIFICATION IN THE ECS(SPSB4) COMPLEX;IDENTIFICATION IN THE ECS(RAB40C) COMPLEX;IDENTIFICATION IN THE ECS(WSB1) COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH LRRC41; SOCS3; SPSB1; SPSB2; SPSB4; WSB1 AND RAB40C
13.

"ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
Kohroki J. , Nishiyama T. , Nakamura T. , Masuho Y.
FEBS Lett.579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASB1; ASB2; ASB6; ASB7 AND ASB12
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation."
Duda D.M. , Borg L.A. , Scott D.C. , Hunt H.W. , Hammel M. , Schulman B.A.
Cell134:995-1006(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 401-780 IN COMPLEX WITH NEDD8 AND RBX1;NEDDYLATION AT LYS-724

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